Deciphering bone formation to model diseases: towards a new generation of in vitro bone models
In this project, we propose a radically new strategy to develop an urgently needed in vitro model of bone formation. Musculoskeletal diseases are commonly associated with insufficient bone formation, that can lead to growth defects, or abnormal bone production in other tissues, such as the joint in arthritis. We have currently no reliable in vitro model to study such phenomena in the laboratory. Here we will characterise the natural process of bone formation, and use this knowledge to create an unprecedented in vitro system. This will provide an invaluable tool for pre-clinical research and drug development for bone disorders.