The main focus of the work is increasing our understanding of the process of endochondral ossification so that we can develop better treatments for large bone defect repair as occurs following trauma, cancer surgery or as a result of congenital anomalies. Elucidating the role of the immune system in MSC mediated bone formation via the process of endochondral ossification is important for two reasons. Firstly, immune cells are intimately involved in the formation and repair of bone tissue. If we are to generate or regenerate bone tissue with MSCs it is necessary to understand how different cells of the immune system are involved. Secondly, it would be preferable to use donor MSCs that do not come from the patient that we might like to treat. To do so we need to understand what the immune response to tissue engineered bone derived from cells from another donor would be. The questions arising from these two issues are the main focus of this research topic.
Niamh Fahy, Virginia Palomares Cabeza, Caoimhe Kiernan (Alumnus)
Frontiers in Immunology, 12:715267