Osteoimmunology; understanding donor host interactions and the role of the immune system in MSC mediated endochondral ossification

The main focus of the work is increasing our understanding of the process of endochondral ossification so that we can develop better treatments for large bone defect repair as occurs following trauma, cancer surgery or as a result of congenital anomalies. Elucidating the role of the immune system in MSC mediated bone formation via the process of endochondral ossification is important for two reasons. Firstly, immune cells are intimately involved in the formation and repair of bone tissue. If we are to generate or regenerate bone tissue with MSCs it is necessary to understand how different cells of the immune system are involved. Secondly, it would be preferable to use donor MSCs that do not come from the patient that we might like to treat. To do so we need to understand what the immune response to tissue engineered bone derived from cells from another donor would be. The questions arising from these two issues are the main focus of this research topic.

People

Niamh Fahy, Virginia Palomares Cabeza, Caoimhe Kiernan (Alumnus)

Related Projects

No related projects at the moment

Related Publications

Chondrogenically Primed Human Mesenchymal Stem Cells Persist and Undergo Early Stages of Endochondral Ossification in an Immunocompetent Xenogeneic Model

Fahy, N., Palomares Cabeza, V., Lolli, A., Witte-Bouma, J., Merino, A., Ridwan, Y., Wolvius, E. B., Hoogduijn, M. J., Farrell, E., Brama, P. A. J. (2021)

Frontiers in Immunology, 12:715267

Allogeneic chondrogenically differentiated human bone marrow stromal cells do not induce dendritic cell maturation

Kiernan, C. H., KleinJan, A., Peeters, M., Wolvius, E. B., Farrell, E., and Brama, P. A. J. (2018)
J Tissue Eng Regen Med 12, 1530-1540

The Immune Response to Allogeneic Differentiated Mesenchymal Stem Cells in the Context of Bone Tissue Engineering

Kiernan, C. H., Wolvius, E. B., Brama, P. A. J., and Farrell, E. (2018)
Tissue Eng Part B Rev 24, 75-83

Pediatric Mesenchymal Stem Cells Exhibit Immunomodulatory Properties Toward Allogeneic T and B Cells Under Inflammatory Conditions

Palomares Cabeza, V., Hoogduijn, M. J., Kraaijeveld, R., Franquesa, M., Witte-Bouma, J., Wolvius, E. B., Farrell, E., and Brama, P. A. J. (2019)
Frontiers in bioengineering and biotechnology 7, 142

Allogeneic Chondrogenic Mesenchymal Stromal Cells Alter Helper T Cell Subsets in CD4+ Memory T Cells

Kiernan, C. H., Asmawidjaja, P. S., Fahy, N., Witte-Bouma, J., Wolvius, E. B., Brama, P. A. J., Lubberts, E., and Farrell, E. (2020)
Tissue Eng Part A