Bone Tissue Engineering Lab

Headed by Eric Farrell and Andrea Lolli


Chondrogenically Primed Human Mesenchymal Stem Cells Persist and Undergo Early Stages of Endochondral Ossification in an Immunocompetent Xenogeneic Model

Fahy, N., Palomares Cabeza, V., Lolli, A., Witte-Bouma, J., Merino, A., Ridwan, Y., Wolvius, E. B., Hoogduijn, M. J., Farrell, E., Brama, P. A. J. (2021)

Frontiers in Immunology, 12:715267

Endothelium-derived stromal cells contribute to hematopoietic bone marrow niche formation
Kenswil, K. J. G., Pisterzi, P., Sanchez-Duffhues, G., van Dijk, C., Lolli, A., Knuth, C., Vanchin, B., Jaramillo, A. C., Hoogenboezem, R. M., Sanders, M. A., Feyen, J., Cupedo, T., Costa, I. G., Li, R., Bindels, E. M. J., Lodder, K., Blom, B., Bos, P. K., Goumans, M. J., Ten Dijke, P., Farrell, E., Krenning, G., and Raaijmakers, M. (2021)
Cell Stem Cell 28, 653-670 e611
Spatiotemporal distribution of thrombospondin-4 and -5 in cartilage during endochondral bone formation and repair.

Andres Sastre, E., Maly, K., Zhu, M., Witte-Bouma, J., Trompet, D., Bohm, A. M., Brachvogel, B., van Nieuwenhoven, C. A., Maes, C., van Osch, G., Zaucke, F., and Farrell, E. (2021)
Bone 150, 115999

Nano-ghosts: Novel biomimetic nano-vesicles for the delivery of antisense oligonucleotides

Oieni, J., Lolli, A., D'Atri, D., Kops, N., Yayon, A., van Osch, G.J.V.M., Machluf, M. (2021)

Journal of Controlled Release, 333:28-40

Cartilage Oligomeric Matrix Protein-Derived Peptides Secreted by Cartilage Do Not Induce Responses Commonly Observed during Osteoarthritis

Andres Sastre, E., Zaucke, F., Witte-Bouma, J., van Osch, G., and Farrell, E. (2020)
Cartilage, 1947603520961170

Angiogenic Potential of Tissue Engineered Cartilage From Human Mesenchymal Stem Cells Is Modulated by Indian Hedgehog and Serpin E1

Nossin, Y., Farrell, E., Koevoet, W., Somoza, R. A., Caplan, A. I., Brachvogel, B., and van Osch, G. (2020) 
Frontiers in bioengineering and biotechnology 8, 327

Allogeneic Chondrogenic Mesenchymal Stromal Cells Alter Helper T Cell Subsets in CD4+ Memory T Cells
Kiernan, C. H., Asmawidjaja, P. S., Fahy, N., Witte-Bouma, J., Wolvius, E. B., Brama, P. A. J., Lubberts, E., and Farrell, E. (2020)
Tissue Eng Part A
Hydrogel-based delivery of antimiR-221 enhances cartilage regeneration by endogenous cells

Lolli, A., Sivasubramaniyan, K., Vainieri, M. L., Oieni, J., Kops, N., Yayon, A., van Osch, G.J.V.M. (2019)

Journal of Controlled Release, 309:220-230

Pediatric Mesenchymal Stem Cells Exhibit Immunomodulatory Properties Toward Allogeneic T and B Cells Under Inflammatory Conditions
Palomares Cabeza, V., Hoogduijn, M. J., Kraaijeveld, R., Franquesa, M., Witte-Bouma, J., Wolvius, E. B., Farrell, E., and Brama, P. A. J. (2019)
Frontiers in bioengineering and biotechnology 7, 142
Collagen type X is essential for successful mesenchymal stem cell-mediated cartilage formation and subsequent endochondral ossification

Knuth, C. A., Andres Sastre, E., Fahy, N. B., Witte-Bouma, J., Ridwan, Y., Strabbing, E. M., Koudstaal, M. J., van de Peppel, J., Wolvius, E. B., Narcisi, R., and Farrell, E. (2019)
Eur Cell Mater 38, 106-122

Calcifications in atherosclerotic plaques and impact on plaque biomechanics
Barrett, H. E., Van der Heiden, K., Farrell, E., Gijsen, F. J. H., and Akyildiz, A. C. (2019)
J Biomech 87, 1-12
Follistatin Effects in Migration, Vascularization, and Osteogenesis in vitro and Bone Repair in vivo.

Fahmy-Garcia, S., Farrell, E., Witte-Bouma, J., Robbesom-van den Berge, I., Suarez, M., Mumcuoglu, D., Walles, H., Kluijtmans, S., van der Eerden, B. C. J., van Osch, G., van Leeuwen, J., and van Driel, M. (2019)
Frontiers in bioengineering and biotechnology 7, 38

Understanding and Modulating Bone and Cartilage Cell Fate for Regenerative Medicine.

Narcisi, R., and Farrell, E. (2019)
Frontiers in bioengineering and biotechnology 7, 8

Allogeneic chondrogenically differentiated human bone marrow stromal cells do not induce dendritic cell maturation
Kiernan, C. H., KleinJan, A., Peeters, M., Wolvius, E. B., Farrell, E., and Brama, P. A. J. (2018)
J Tissue Eng Regen Med 12, 1530-1540
The Immune Response to Allogeneic Differentiated Mesenchymal Stem Cells in the Context of Bone Tissue Engineering
Kiernan, C. H., Wolvius, E. B., Brama, P. A. J., and Farrell, E. (2018)
Tissue Eng Part B Rev 24, 75-83
Isolating Pediatric Mesenchymal Stem Cells with Enhanced Expansion and Differentiation Capabilities
Knuth, C. A., Kiernan, C. H., Palomares Cabeza, V., Lehmann, J., Witte-Bouma, J., Ten Berge, D., Brama, P. A., Wolvius, E. B., Strabbing, E. M., Koudstaal, M. J., Narcisi, R., and Farrell, E. (2018)
Tissue Eng Part C Methods 24, 313-321
Mesenchymal stem cell-mediated endochondral ossification utilising micropellets and brief chondrogenic priming
Knuth, C. A., Witte-Bouma, J., Ridwan, Y., Wolvius, E. B., and Farrell, E. (2017)
Eur Cell Mater 34, 142-161
Selective laser melting porous metallic implants with immobilized silver nanoparticles kill and prevent biofilm formation by methicillin-resistant Staphylococcus aureus
A., Zaat, S. A. J., and Apachitei, I. (2017)
Biomaterials 140, 1-15
Silencing of Antichondrogenic MicroRNA-221 in Human Mesenchymal Stem Cells Promotes Cartilage Repair In Vivo

Lolli, A., Narcisi, R., Lambertini, E., Penolazzi, L., Angelozzi, M., Kops, N., Gasparini, S., van Osch, G.J.V.M., Piva, R. (2016)

Stem Cells, 34:1801-11

Differentiation of Vascular Stem Cells Contributes to Ectopic Calcification of Atherosclerotic Plaque
Leszczynska, A., O'Doherty, A., Farrell, E., Pindjakova, J., O'Brien, F. J., O'Brien, T., Barry, F., and Murphy, M. (2016)
Stem Cells 34, 913-923