The current gold-standard treatment for large bone defects involves autologous transplantation, despite its associated risks, such as donor site morbidity, increased risk of infection, and limited tissue availability. As a result, significant efforts have been made in the field of bone tissue engineering to address the growing demand for transplantable bone.
The ADDBONE project is a public private partnership which seeks to translate bone tissue engineering to the clinic. In collaboration with our partners, the project combines biodegradable microcarriers from IamFluidics with a large-scale bioreactor expansion technique from Scinus Netherlands B.V.. In this bioreactor, paediatric mesenchymal stem cells (p-MSCs) will be expanded and chondrogenically differentiated, with the potential for implantation into patients for bone formation.
Image: Live-dead stain of human MSCs on microcarriers from IamFluidics
Websites: Scinus Cell Expansion and IamFluidics