Publications | Farrell Lab

Osteoclast Incorporation in an In Vitro 3D Model of Endochondral Ossification

Garmendia Urdalleta A, Witte-Bouma J, Kops N, Lolli A, Farrell E. Osteoclast Incorporation in an In Vitro 3D Model of Endochondral Ossification, (2025), Tissue Eng Part A.

Modelling Atherosclerotic Plaque Cap Mechanics: Microcalcifications Reduce Mechanical Properties in Mesenchymal Stromal Cell-Based Model

Jansen IL, Şahin D, Gijsen FJH, Farrell E, van der Heiden K. Modelling Atherosclerotic Plaque Cap Mechanics: Microcalcifications Reduce Mechanical Properties in Mesenchymal Stromal Cell-Based Model, (2025) Adv Biol (Weinh).

The effect of presence and location of microcalcifications on atherosclerotic plaque rapture: A tissue-engineering approach

Crielaard H, Jansen I, van der Heiden K, Kremers GJ, Gijsen FJH, Farrell E, Akyildiz AC. The effect of presence and location of microcalcifications on atherosclerotic plaque rupture: A tissue-engineering approach, (2025), J Mech Behav Biomed Mater.

Additively manufactured biodegradable porous FeMn-akermanite scaffolds for critical-size bone defects: the first in vivo evaluation

Putra NE, Xu J, Leeflang MA, Kops N, Klimopoulou M, Moosabeiki V, Fratila-Apachitei LE, Zhou J, van Osch GJVM, Farrell E, Zadpoor AA. Additively manufactured biodegradable porous FeMn-akermanite scaffolds for critical-size bone defects: the first in vivo evaluation, (2025), Mater Today Bio..

Investigating the impact of microcalcification size and volume on collagenous matrix and tissue mechanics using a tissue-engineered atherosclerotic cap model

Jansen IL, Șahin D, Gijsen FJH, Farrell E, van der Heiden K. Investigating the impact of microcalcification size and volume on collagenous matrix and tissue mechanics using a tissue-engineered atherosclerotic cap model, (2025), Front Cardiovasc Med.

Development of a Complex Human In Vitro Model of Endochondral Ossification

Ji E, Garmendia Urdalleta A, Witte-Bouma J, Kremers GJ, Di Maggio N, Banfi A, Farrell E, Lolli A. Development of a Complex Human In Vitro Model of Endochondral Ossification, (2025), Tissue Eng Part C Methods.

Incorporating strontium enriched amorphous calcium phosphate granules in collagen/collagen-magnesium-hydroxyapatite osteochondral scaffolds improves subchondral bone repair

Xu J.; Vecstaudza J.; Wesdorp M.A.; Labberté M.; Kops N.; Salerno M.; Kok J.; Simon M.; Harmand M.-F.; Vancíková K.; van Rietbergen B.; Misciagna M.M.; Dolcini L.; Filardo G.; Farrell E.; van Osch G.J.V.M.; Locs J.; Brama P.A.J. (2024), Materials Today Bio, 25:100959

Bone formation by human paediatric marrow stromal cells in a functional allogeneic immune system

Palomares Cabeza V.; Fahy N.; Kiernan C.H.; Lolli A.; Witte-Bouma J.; Fahmy Garcia S.; Merino A.; Kops N.; Ridwan Y.; Wolvius E.B.; Brama P.A.J.; Hoogduijn M.J.; Farrell E. (2024), Biomaterials, 306:122471

The interplay of collagen, macrophages, and microcalcification in atherosclerotic plaque cap rupture mechanics

Jansen I.; Cahalane R.; Hengst R.; Akyildiz A.; Farrell E.; Gijsen F.; Aikawa E.; van der Heiden K.; Wissing T. (2024), Basic Research in Cardiology, 119:2

In Vitro Mineralisation of Tissue-Engineered Cartilage Reduces Endothelial Cell Migration, Proliferation and Tube Formation

Ji E.; Leijsten L.; Witte-Bouma J.; Rouchon A.; Di Maggio N.; Banfi A.; van Osch G.J.V.M.; Farrell E.; Lolli A. (2023), Cells, 12:8:1202

Effectiveness of BMP-2 and PDGF-BB Adsorption onto a Collagen/Collagen-Magnesium-Hydroxyapatite Scaffold in Weight-Bearing and Non-Weight-Bearing Osteochondral Defect Bone Repair

Xu J.; Fahmy-Garcia S.; Wesdorp M.A.; Kops N.; Forte L.; De Luca C.; Misciagna M.M.; Dolcini L.; Filardo G.; Labberté M.; Vancíková K.; Kok J.; van Rietbergen B.; Nickel J.; Farrell E.; Brama P.A.J.; van Osch G.J.V.M. (2023), Journal of Functional Biomaterials, 14:2:111

Why Animal Experiments Are Still Indispensable in Bone Research: A Statement by the European Calcified Tissue Society

Stein M.; Elefteriou F.; Busse B.; Fiedler I.A.K.; Kwon R.Y.; Farrell E.; Ahmad M.; Ignatius A.; Grover L.; Geris L.; Tuckermann J. (2023), Journal of Bone and Mineral Research, 38:8

The response of human macrophages to 3D printed titanium antibacterial implants does not affect the osteogenic differentiation of hMSCs

Garmendia Urdalleta A.; Van Poll M.; Fahy N.; Witte-Bouma J.; Van Wamel W.; Apachitei I.; Zadpoor A.A.; Fratila-Apachitei L.E.; Farrell E. (2023), Frontiers in Bioengineering and Biotechnology, 11:1176534

A tissue-engineered model of the atherosclerotic plaque cap: Toward understanding the role of microcalcifications in plaque rupture

Jansen I.; Crielaard H.; Wissing T.; Bouten C.; Gijsen F.; Akyildiz A.C.; Farrell E.; van der Heiden K. (2023), APL Bioengineering, 7:3

Addition of heparin binding sites strongly increases the bone forming capabilities of BMP9 in vivo

Siverino C.; Fahmy-Garcia S.; Niklaus V.; Kops N.; Dolcini L.; Misciagna M.M.; Ridwan Y.; Farrell E.; van Osch G.J.V.M.; Nickel J. (2023), Bioactive Materials, 29

Site-Directed Immobilization of an Engineered Bone Morphogenetic Protein 2 (BMP2) Variant to Collagen-Based Microspheres Induces Bone Formation In Vivo

Siverino C.; Fahmy-Garcia S.; Mumcuoglu D.; Oberwinkler H.; Muehlemann M.; Mueller T.; Farrell E.; van Osch G.J.V.M.; Nickel J. (2022), International Journal of Molecular Sciences, 23:7:3928

Spatiotemporal distribution of thrombospondin-4 and -5 in cartilage during endochondral bone formation and repair.

Andres Sastre, E., Maly, K., Zhu, M., Witte-Bouma, J., Trompet, D., Bohm, A. M., Brachvogel, B., van Nieuwenhoven, C. A., Maes, C., van Osch, G., Zaucke, F., and Farrell, E. (2021)
Bone 150, 115999

Endothelium-derived stromal cells contribute to hematopoietic bone marrow niche formation

Kenswil, K. J. G., Pisterzi, P., Sanchez-Duffhues, G., van Dijk, C., Lolli, A., Knuth, C., Vanchin, B., Jaramillo, A. C., Hoogenboezem, R. M., Sanders, M. A., Feyen, J., Cupedo, T., Costa, I. G., Li, R., Bindels, E. M. J., Lodder, K., Blom, B., Bos, P. K., Goumans, M. J., Ten Dijke, P., Farrell, E., Krenning, G., and Raaijmakers, M. (2021)
Cell Stem Cell 28, 653-670 e611

Nano-ghosts: Novel biomimetic nano-vesicles for the delivery of antisense oligonucleotides

Oieni, J., Lolli, A., D'Atri, D., Kops, N., Yayon, A., van Osch, G.J.V.M., Machluf, M. (2021)

Journal of Controlled Release, 333:28-40

Chondrogenically Primed Human Mesenchymal Stem Cells Persist and Undergo Early Stages of Endochondral Ossification in an Immunocompetent Xenogeneic Model

Fahy, N., Palomares Cabeza, V., Lolli, A., Witte-Bouma, J., Merino, A., Ridwan, Y., Wolvius, E. B., Hoogduijn, M. J., Farrell, E., Brama, P. A. J. (2021)

Frontiers in Immunology, 12:715267

A new semi-orthotopic bone defect model for cell and biomaterial testing in regenerative medicine

Andrés Sastre E.; Nossin Y.; Jansen I.; Kops N.; Intini C.; Witte-Bouma J.; van Rietbergen B.; Hofmann S.; Ridwan Y.; Gleeson J.P.; O'Brien F.J.; Wolvius E.B.; van Osch G.J.V.M.; Farrell E. (2021), Biomaterials, 279:121187

The Releasate of Avascular Cartilage Demonstrates Inherent Pro-Angiogenic Properties In Vitro and In Vivo

Nossin Y.; Farrell E.; Koevoet W.J.L.M.; Datema F.; Somoza R.A.; Caplan A.I.; van Osch G.J.V.M. (2021), Cartilage, 13:2

Bio-inspired polymeric iron-doped hydroxyapatite microspheres as a tunable carrier of rhBMP-2

Fernandes Patrício T.M.; Mumcuoglu D.; Montesi M.; Panseri S.; Witte-Bouma J.; Garcia S.F.; Sandri M.; Tampieri A.; Farrell E.; Sprio S. (2021), Materials Science and Engineering C, 119:111410

Comp and tsp-4: Functional roles in articular cartilage and relevance in osteoarthritis

Maly K.; Sastre E.A.; Farrell E.; Meurer A.; Zaucke F. (2021), International Journal of Molecular Sciences, 22:5:2242

Angiogenic Potential of Tissue Engineered Cartilage From Human Mesenchymal Stem Cells Is Modulated by Indian Hedgehog and Serpin E1

Nossin, Y., Farrell, E., Koevoet, W., Somoza, R. A., Caplan, A. I., Brachvogel, B., and van Osch, G. (2020)
Frontiers in bioengineering and biotechnology 8, 327

Cartilage Oligomeric Matrix Protein-Derived Peptides Secreted by Cartilage Do Not Induce Responses Commonly Observed during Osteoarthritis

Andres Sastre, E., Zaucke, F., Witte-Bouma, J., van Osch, G., and Farrell, E. (2020)
Cartilage, 1947603520961170

Allogeneic Chondrogenic Mesenchymal Stromal Cells Alter Helper T Cell Subsets in CD4+ Memory T Cells

Kiernan, C. H., Asmawidjaja, P. S., Fahy, N., Witte-Bouma, J., Wolvius, E. B., Brama, P. A. J., Lubberts, E., and Farrell, E. (2020)
Tissue Eng Part A

Understanding and Modulating Bone and Cartilage Cell Fate for Regenerative Medicine.

Narcisi, R., and Farrell, E. (2019)
Frontiers in bioengineering and biotechnology 7, 8

Collagen type X is essential for successful mesenchymal stem cell-mediated cartilage formation and subsequent endochondral ossification

Knuth, C. A., Andres Sastre, E., Fahy, N. B., Witte-Bouma, J., Ridwan, Y., Strabbing, E. M., Koudstaal, M. J., van de Peppel, J., Wolvius, E. B., Narcisi, R., and Farrell, E. (2019)
Eur Cell Mater 38, 106-122

Follistatin Effects in Migration, Vascularization, and Osteogenesis in vitro and Bone Repair in vivo.

Fahmy-Garcia, S., Farrell, E., Witte-Bouma, J., Robbesom-van den Berge, I., Suarez, M., Mumcuoglu, D., Walles, H., Kluijtmans, S., van der Eerden, B. C. J., van Osch, G., van Leeuwen, J., and van Driel, M. (2019)
Frontiers in bioengineering and biotechnology 7, 38

Calcifications in atherosclerotic plaques and impact on plaque biomechanics

Barrett, H. E., Van der Heiden, K., Farrell, E., Gijsen, F. J. H., and Akyildiz, A. C. (2019)
J Biomech 87, 1-12

Hydrogel-based delivery of antimiR-221 enhances cartilage regeneration by endogenous cells

Lolli, A., Sivasubramaniyan, K., Vainieri, M. L., Oieni, J., Kops, N., Yayon, A., van Osch, G.J.V.M. (2019)

Journal of Controlled Release, 309:220-230

Isolating Pediatric Mesenchymal Stem Cells with Enhanced Expansion and Differentiation Capabilities

Knuth, C. A., Kiernan, C. H., Palomares Cabeza, V., Lehmann, J., Witte-Bouma, J., Ten Berge, D., Brama, P. A., Wolvius, E. B., Strabbing, E. M., Koudstaal, M. J., Narcisi, R., and Farrell, E. (2018)
Tissue Eng Part C Methods 24, 313-321

Pediatric Mesenchymal Stem Cells Exhibit Immunomodulatory Properties Toward Allogeneic T and B Cells Under Inflammatory Conditions

Palomares Cabeza, V., Hoogduijn, M. J., Kraaijeveld, R., Franquesa, M., Witte-Bouma, J., Wolvius, E. B., Farrell, E., and Brama, P. A. J. (2019)
Frontiers in bioengineering and biotechnology 7, 142

The Immune Response to Allogeneic Differentiated Mesenchymal Stem Cells in the Context of Bone Tissue Engineering

Kiernan, C. H., Wolvius, E. B., Brama, P. A. J., and Farrell, E. (2018)
Tissue Eng Part B Rev 24, 75-83

Allogeneic chondrogenically differentiated human bone marrow stromal cells do not induce dendritic cell maturation

Kiernan, C. H., KleinJan, A., Peeters, M., Wolvius, E. B., Farrell, E., and Brama, P. A. J. (2018)
J Tissue Eng Regen Med 12, 1530-1540

Selective laser melting porous metallic implants with immobilized silver nanoparticles kill and prevent biofilm formation by methicillin-resistant Staphylococcus aureus

A., Zaat, S. A. J., and Apachitei, I. (2017)
Biomaterials 140, 1-15

Mesenchymal stem cell-mediated endochondral ossification utilising micropellets and brief chondrogenic priming

Knuth, C. A., Witte-Bouma, J., Ridwan, Y., Wolvius, E. B., and Farrell, E. (2017)
Eur Cell Mater 34, 142-161

Differentiation of Vascular Stem Cells Contributes to Ectopic Calcification of Atherosclerotic Plaque

Leszczynska, A., O'Doherty, A., Farrell, E., Pindjakova, J., O'Brien, F. J., O'Brien, T., Barry, F., and Murphy, M. (2016)
Stem Cells 34, 913-923

Silencing of Antichondrogenic MicroRNA-221 in Human Mesenchymal Stem Cells Promotes Cartilage Repair In Vivo

Lolli, A., Narcisi, R., Lambertini, E., Penolazzi, L., Angelozzi, M., Kops, N., Gasparini, S., van Osch, G.J.V.M., Piva, R. (2016)

Stem Cells, 34:1801-11

Cell labelling with superparamagnetic iron oxide has no effect on chondrocyte behaviour

Farrell E.; Wielopolski P.; Pavljasevic P.; Kops N.; Weinans H.; Bernsen M.R.; van Osch G.J.V.M. (2009), Osteoarthritis and Cartilage, 17:7

Chondrogenic priming of human bone marrow stromal cells: A better route to bone repair?

Farrell E.; Van Der Jagt O.P.; Koevoet W.; Kops N.; Van Manen C.J.; Hellingman C.A.; Jahr H.; O'Brien F.J.; Verhaar J.A.N.; Weinans H.; Van Osch G.J.V.M. (2009), Tissue Engineering - Part C: Methods, 15:2

Effects of iron oxide incorporation for long term cell tracking on MSC differentiation in vitro and in vivo

Farrell E.; Wielopolski P.; Pavljasevic P.; van Tiel S.; Jahr H.; Verhaar J.; Weinans H.; Krestin G.; O'Brien F.J.; van Osch G.; Bernsen M. (2008), Biochemical and Biophysical Research Communications, 369:4

Gene expression by marrow stromal cells in a porous collagen- glycosaminoglycan scaffold is affected by pore size and mechanical stimulation

Byrne E.M.; Farrell E.; McMahon L.A.; Haugh M.G.; O'Brien F.J.; Campbell V.A.; Prendergast P.J.; O'Connell B.C. (2008), Journal of Materials Science: Materials in Medicine, 19:11

A comparison of the osteogenic potential of adult rat mesenchymal stem cells cultured in 2-D and on 3-D collagen glycosaminoglycan scaffolds

Farrell E.; Byrne E.M.; Fischer J.; O'Brien F.J.; O'Connell B.C.; Prendergast P.J.; Campbell V.A. (2007), Technology and Health Care, 15:1

A collagen-glycosaminoglycan scaffold supports adult rat mesenchymal stem cell differentiation along osteogenic and chondrogenic routes

Farrell E.; O'Brien F.J.; Doyle P.; Fischer J.; Yannas I.; Harley B.A.; O'Connell B.; Prendergast P.J.; Campbell V.A. (2006), Tissue Engineering, 12:3

Influence of strong static magnetic fields on primary cortical neurons

Prina-Mello A.; Farrell E.; Prendergast P.J.; Campbell V.; Coey J.M.D. (2006), Bioelectromagnetics, 27:1

Effects of static magnetic fields on primary cortical neurons

Mello A.P.; Farrell E.; Prendergast P.J.; Campbell V.; Coey J.M.D. (2005), Physica Scripta T